What is Celkeran 2mg ?
Celkeran belongs to the group of medicines called alkylating agents. It is used to treat different types of cancer of the blood and lymph system, such as chronic lymphatic leukemia, Hodgkin's disease, and other types of lymphoma.
Celkeran interferes with the growth of cancer cells, which are eventually destroyed. Since the growth of normal cells may also be affected by Celkeran, other effects may also occur. Some of these may be serious and must be reported to your doctor. Other effects may not be serious but may cause concern. Some effects may occur after treatment with Celkeran has been stopped.
Before you begin treatment with Celkeran, you and your doctor should talk about the benefits Celkeran will do as well as the risks of using it.
Celkeran is available only with your doctor's prescription.
Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although these uses are not included in product labeling, Celkeran is used in certain patients with the following medical conditions:
- Cancer of the lymph system that affects the skin.
- Cancer of the ovaries.
- Hairy cell leukemia (a cancer of the blood and bone marrow).
- Histiocytosis X (a certain type of cancer found primarily in children).
- Nephrotic syndrome (a kidney disease).
- Tumors in the uterus (womb).
- Waldenström's macroglobulinemia (a certain type of cancer of the blood).
Side effects of Celkeran 2mg Tablet
- Mouth ulcer
- Decreased blood cells (red cells, white cells, and platelets)
- Bone-marrow suppression
- Decreased white blood cell count
- Decreased white blood cell count (neutrophils)
How to use Celkeran 2mg Tablet
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. It is better to take Celkeran 2mg Tablet empty stomach (1 hour before food or 2 hours after food).
How Celkeran 2mg Tablet works
Celkeran 2mg tablet is an anti-cancer medication. It works by damaging the genetic material (DNA) of the cancer cells and stops their growth and multiplication.
Expert advice for Celkeran 2mg Tablet
- Do not receive live vaccine (such as measles, mumps, rubella and others) while using chlorambucil, and avoid contact with anyone who has recently received a live vaccine as there are chances that the virus could be passed on to you.
- You may be regularly monitored for blood count while taking chlorambucil.
- Do not take chlorambucil if you have recently undergone radiotherapy or received other cytotoxic agents.
- Caution has to be followed if you have a liver or kidney problems.
- Regular monitoring is required if your child is having nephrotic syndrome; or if you have been prescribed high pulse dosing regimens and have a history of seizure disorder.
- Do not take chlorambucil if you have rare hereditary problems of glucose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption should not take this medication.
- Tell your doctor if you are or planning to become pregnant or are breastfeeding.
Pregnancy : Celkeran 2mg Tablet may be unsafe to use during pregnancy. Animal studies have shown adverse effects on the foetus, however, there are limited human studies. The benefits from use in pregnant women may be acceptable despite the risk. Please consult your doctor.
Lactation : Celkeran 2mg Tablet is usafe to use during lactation. Data suggests that the drug may cause toxicity to the baby, or the mother is suffering from a condition in which breast feeding is not advisable.
Driving : It is not known whether Celkeran 2mg Tablet alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react.
Kidney : Celkeran 2mg Tablet should be used with caution in patients with kidney disease. Dose adjustment of Celkeran 2mg Tablet may be needed. Please consult your doctor.Careful monitoring by a doctor is important as kidney disease patients are at an increased risk of bone marrow depression and inflammation and infections of urinary bladder while taking this medicine.
Liver : There is limited information available on the use of Celkeran 2mg Tablet in patients with liver disease. Please consult your doctor.
If you miss a dose of Chlorambucil, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Frequently asked questions for Celkeran 2mg :
Q. How is Celkeran administered?
Celkeran is administered orally in tablet form
Q. Why is Celkeran toxic to cancer cells/ how does Celkeran work?
Celkeran belongs to a class of drugs called nitrogen mustard derivatives which kill the cancer cells by interfering with DNA replication, and also by directly slowing or stopping their growth
Q. Does Celkeran cause hair loss/constipation?
No, hair loss or constipation has not been reported with the use of Celkeran.
Q. What is Celkeran used for?
Celkeran is used to treat some types of blood cancers like Hodgkin's disease (cancer that starts in blood cells that are part of immune system), certain forms of non-Hodgkin's lymphoma, chronic lymphocytic leukemia (disease where the bone marrow produces a large number of abnormal white cells. It is also used to treat Waldenstrom's macroglobulinaemia (rare blood condition involving the release of an abnormal protein, macroglobulin, into the blood)
Q. How is Celkeran excreted?
Celkeran is metabolized in liver to form nontoxic compounds which are excreted in urine
Q. Does Celkeran need to be refrigerated?
Celkeran has to be stored in a refrigerator at 2 °C – 8 °C