Buy Xbira 250mg Online
Xbira 250 mg Tablet is an anticancer drug used in men along with another drug called prednisone for the treatment of prostate cancer that has spread to other parts of the body. It is generally used in patients who are not responding to other treatment options.
How To Xbira 250mg Work?
Abiraterone is known as an androgen biosynthesis inhibitor. Androgens stimulate prostate cancer cells to grow. The main androgens in the body are testosterone. Almost all testosterone in men is made by the testicles. A very small amount is made by the adrenal glands, which sit above the kidneys. Abiraterone reduces the amount of testosterone made by your body. This reduces testosterone levels and may shrink the prostate cancer or stop it growing.
What is Xbira 250mg Tablet?
Xbira belongs to the group of medications called antineoplastics, or anti-cancer medications. It contains a medicine called Abiraterone Acetate. It is a prescription medicine that can be purchased by a patient only against a valid prescription of a healthcare professional. Do not share this cancer medicine with others because it can cause serious side effects to people until the condition is not monitored by a pharmacist.
Mechanism Action Of Xbira 250mg?
Abiraterone acetate is converted in vivo to abiraterone, an androgen biosynthesis inhibitor, that inhibits 17alpha-hydroxylase/C17,20-lyase (CYP17). This enzyme is expressed in testicular, adrenal and prostatic tumour tissues and is required for androgen biosynthesis.
Cytochrome (CY) P17 catalyses two sequential reactions: 1) the conversion of pregnenolone and progesterone to their 17alpha-hydroxy derivatives by 17alpha-hydroxylase activity and, 2) the subsequent formation of dehydroepiandrosterone (DHEA) and androstenedione, respectively by C17,20 lyase activity. DHEA and androstenedione are androgens and are precursors of testosterone. Inhibition of CYP17 by abiraterone can also result in increased mineralocorticoid production by the adrenals.
Androgen-sensitive prostatic carcinoma responds to treatment that decreases androgen levels. Androgen-deprivation therapies, such as treatment with gonadotropin-releasing hormone (GnRH) agonists or orchiectomy, decrease androgen production in the testes but do not affect androgen production by the adrenals or in the tumour.
Abiraterone acetate decreased serum testosterone and other androgens in patients in the placebo-controlled Phase 3 clinical trial. It is not necessary to monitor the effect of abiraterone acetate on serum testosterone levels.
Changes in serum prostate-specific antigen (PSA) levels may be observed, but have not been shown to correlate with clinical benefit in individual patients.
Side Effects of Xbira 250mg
- Increased blood pressure
- Irregular heartbeat
- Swelling of ankles or feet
- Nausea and vomiting
- Shortness of breath
- Urinary tract infection
- Increased cholesterol and triglycerides
Warning of Xbira 250mg tablet
Abiraterone acetate must be taken at least one hour before or two hours after eating and never with food. Do not break, crush, or chew before swallowing abiraterone acetate tablets.
Men who take abiraterone acetate should always use effective birth control measure when having physical relationship with a woman who is or may become pregnant.
Contact your doctor if you experience any bone pain. An increased occurrence of bone fractures has been reported in patients using abiraterone acetate.
Before you take abiraterone acetate tell your doctor if you have high blood sugar, swelling in the feet, ankles, or legs or any effects on your bones or have taken a medicine known as ketoconazole in the past for prostate cancer.
You must inform your doctor or dentist that you take abiraterone acetate before receiving any medical or dental care, emergency care, or surgery.
Precaution of Xbira 250mg tablet
Patients should be informed that abiraterone acetate and prednisone are used together and that they should not interrupt or stop either of these medications without consulting their physician.
Patients receiving GnRH agonists should be informed that they need to maintain this treatment during the course of treatment with abiraterone acetate and prednisone.
Patients should be informed that abiraterone acetate must not be taken with food and that no food should be consumed for at least 2 hours before the dose of abiraterone acetate is taken and for at least 1 hour after the dose of abiraterone acetate is taken. They should be informed that the tablets should be swallowed whole with water without crushing or chewing. Patients should be informed that taking abiraterone acetate with food causes increased exposure and this may result in adverse reactions.
Patients should be informed that the recommended dosage of abiraterone acetate is once daily while prednisone is taken twice daily, and they should be taken according to their physician’s instructions.
Patients should be informed that in the event of a missed daily dose of abiraterone acetate or prednisone, they should take their normal dose the following day. If more than one daily dose is skipped, patients should be told to inform their physician.
Patients should be apprised of the common side effects associated with abiraterone acetate, including peripheral oedema, hypokalaemia, hypertension, elevated liver function tests, and urinary tract infection.
Patients should be advised that their liver function will be monitored using blood tests.
Patients should be informed that abiraterone acetate may harm a developing foetus; thus, women who are pregnant or women who may be pregnant should not handle abiraterone acetate without protection, e.g. gloves. Patients should also be informed that it is not known whether abiraterone or its metabolites are present in semen and they should use a condom if having sex with a pregnant woman. The patient should use a condom and another effective method of birth control if he is having sex with a woman of childbearing potential. These measures are required during and for one week after treatment with abiraterone acetate.
Uses of Xbira 250mg
Xbira 250mg Tablet is used in the treatment of prostate cancer. Xbira (Abiraterone Acetate) is indicated for use in combination with other medicine for the treatment of men with metastatic castration-resistant prostate cancer.
Storage of Xbira 250mg
- Store Abiraterone at 20°C to 25°C (68°F to 77°F); excursions are permitted between 15°C and 30°C (59°F and 86°F).
- Store it in a cool, dry place, protected from light and refrigerated when necessary. Improper storage can affect the effectiveness and shelf life of your medicine.
- Consider storing your medications separately from your other family members. You can put them on a different shelf, or in a different cabinet or drawer.
- If you're driving, you may want to have certain medicines at hand, but don't store them in the glove compartment, where they could be damaged from the heat, cold, or rain outside or from the car's heater or air conditioner.
- Always remember to store your medication out of sight and reach of children and pets, to prevent accidental ingestion.