Xtane 25 mg Tablet
Xtane 25Mg Tablet is a medication prescribed for the treatment of breast cancer. Xtane 25Mg Tablet belongs to a family of anti-estrogens and is mostly used to arrest the synthesis of estrogen by the release of an enzyme known as aromatase. Certain types of breast cancer are ER-positive and have estrogen receptors that require estrogen to grow and spread. Therefore it is important to lower the estrogen levels to decelerate the spread of the hormone-responsive cancer. The drug may also be used to treat advanced stages of breast cancer in postmenopausal women, where there has been a consistent progress in the disease following tamoxifen therapy.
Xtane 25Mg Tablet is mostly used to treat women who have reached menopausal years, with early symptoms of hormone-receptor-positive breast cancer. However the medication is contraindicated in pregnant, premenopausal or lactating women.
Common side effects of Xtane 25Mg Tablet include severe joint pain, headaches, hot flashes and excessive sweating which are typical symptoms of estrogen deficiency, as caused by the drug. Patients of breast cancer also exhibit symptoms of exhaustion and nausea. Sudden outbreaks of acne or weight gain are also associated with the dosage of the drug. Xtane 25Mg Tablet is known to have androgenic properties like that of formestane, and may also cause a decline in lymphocytes.
Side Effects Of Tablets
In general, Xtane is well tolerated and the following side effects observed in patients treated with Generic Exemestane are mainly mild or moderate in nature.
Hypersensitivity, inflammation of the liver (hepatitis) and inflammation of the bile ducts of the liver which cause yellowing of the skin (cholestatic hepatitis) can occur in certain patients. Symptoms include feeling generally unwell, nausea, jaundice (yellowing of the skin and eyes), itching, right sided abdominal pain and loss of appetite. Contact your doctor immediately to seek urgent medical advice if you think you have any of these symptoms. The very common side effects (may affect more than 1 in 10 people) are:
- Difficulty sleeping
- Hot flushes
- Feeling sick
- Increased sweating
- Muscle and joint pain (including osteoarthritis, back pain, arthritis and joint stiffness)
- A reduction in the number of white blood cells
- Abdominal pain
- Elevated level of liver enzymes
- Elevated level of a hemoglobin breakdown in the blood
- Elevated level of a blood enzyme in the blood due to liver damage
Uses of Xtane
Xtane is an aromatase inhibitor which is used for the adjuvant treatment of postmenopausal women with estrogen-receptor positive early breast cancer who have received two to three years of Tamoxifen and are switched to Xtane for completion of a total of five consecutive years of adjuvant hormonal therapy. It is also used for the treatment of advanced breast cancer in postmenopausal women whose disease has progressed following Tamoxifen therapy.
Xtane - Dosage
The recommended dosage of Xtane tablets is 25 mg orally once a day, after meals.
Generic Exemestane tablets should be taken by mouth after a meal at approximately the same time each day. Your doctor will let you know how to take Xtane and for how long.
After a single dose of 25 mg given after a meal, average peak plasma levels of 18 ng/mL are achieved within 2 hours post-dosing. Food was observed to enhance absorption.
Warnings and Precautions
Please inform your doctor if you are taking, have recently taken or might take any other medicines, including medicines obtained without a prescription. The other warnings and precautions are:
Before starting treatment with Aromex, your doctor may want to take blood samples to confirm you have reached the menopause.
Routine checking of your vitamin D level will also be made before treatment, as your level could be very low in the early stages of breast cancer. You will be given vitamin D supplement if your levels are below normal.
Before taking Aromex, inform your doctor if you have problems with your liver or kidneys.
Inform your doctor if you have a history or are suffering from any condition which affects the strength of your bones. Your doctor may want to measure your bone density before and during the treatment of Generic Exemestane. This is because medicines of this class lower the levels of female hormones and this may lead to a loss of the mineral content of bones, which might decrease their strength.